Synthesis of 1-((4-methoxyphenyl)-3-alkynes)-1 H -pyrrole-2,5-diones and functionalization to triazoles

Synthesis and Biological Activity of Certain Mannich Bases Derivatives from 1, 2, 4-Triazoles

Substituted 1, 2, 4- Triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. These triazoles were used for preparation of different derivatives by two different schemes. In the first scheme the Mannich bases were prepared from 5- marcapto-s triazole Quinazolines. The 5-Marcato-s-Tr...

Ethyl 1’-[1-(4-methoxyphenyl)-3-phenoxy-4-phenylazetidin-1-yl]-1,3-dioxo-2′,3′,5′,6′,7′,7a′-hexahydroindan-2-spiro-3′-1′H-pyrrolizine-2′-carboxylate

In the title compound, C(34)H(32)N(2)O(7), the methyl group and methylene H atoms of the ethoxycarbonyl substituent are disordered over two positions with site occupancy factors for the major and minor conformers of 0.594 (8) and 0.406 (8), respectively. The unsubstituted ring of the pyrrolizine ring system exhibits a twist conformation, the other an envelope conformation. In the crystal struct...

Synthesis and study of anticonvulsant effect of 1-[1-(4-methoxyphenyl) (cyclohexyl)] 4-piperidinol as a new derivative of phencyclidine in PTZ-induced kindling model in male mice

Background and Objective: Epilepsy is a common disease in communities. Since there is no cure for it and current treatments are not effective for every patient, new method for medical treatment of epileptic patients is necessary. As NMDA receptors antagonists are the most prominent anti-epileptic drugs, in this study we synthesized and investigated anti-epileptic effect of a new piperidine deri...

Synthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines

A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...

Synthesis of 2-(4-methoxyphenyl)ethanol[ring-1-14C].